Figure 9.

Distribution of ¹²⁵I-IL-8 following intratracheal instillation alone or in the presence of DEP or silica particles. Rats were instilled with the suspensions and killed at intervals thereafter. The various organs were isolated, lungs were lavaged, and the fraction of the initial level of the label present in each fraction is plotted as a function of time. A: percent of administered label in the lung. B: percent of administered label in the GI tract. C: percent of administered label in the thyroid. D: percent of the lung label in BAL pellet. E: percent of the lung label in BAL fluid supernatant. F: percent of lung label in lung tissue. IL-8 alone: solid squares, dotted lines. IL-8 + DEP: open circles, solid line. IL-8 + silica: solid triangles, dashed line.