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. Author manuscript; available in PMC: 2008 Nov 21.
Published in final edited form as: Leukemia. 2008 Apr 3;22(6):1191–1199. doi: 10.1038/leu.2008.74

Figure 7.

Figure 7

Cytotoxic effects of Gleevec and β-phenylethyl isothiocyanate (PEITC) in cells with or without BCR-ABL expression and relationship with ROS generation. (a) The murine myeloid 32D cells (without BCR-ABL) and the Bcr-Abl stable transfectant line (32D-BCR-ABL cells) were incubated with 10 μm PEITC or 5 μm Gleevec for 24 h, and cell death was measured by the annexin-V/PI double staining followed by flow cytometry analysis. (b) Effect of PEITC (10 μm, 2 h) and Gleevec (5 μm, 2 h) on cellular ROS contents. Cellular ROS were measured by flow cytometric analysis after the cells were stained with CM-H2DCF-DA fluorescence dye.