Table 1. Results of the tagging SNP A+930→G (genetic dominant model) for A) the Cox model for T2DM in EPIC, B) the logistic regression model in MeSyBePo, C) the logistic regression model in the Leipzig cohort and D) for the linear regression model of D1) ISI-insulin sensitivity, D2) AUCInsulin/AUCGlucose-insulin secretion, D3) DI-disposition index.
| A) | |||
| Genotype (nsubcohort/nexternal cases) | Hazard Ratio (95%CI) | p-value | |
| GG (1,835/563) | 1 (reference) | ||
| GA+AA (399+32/118+10) | 0.86 (0.66–1.13) | 0.3 | |
| B) | |||
| Genotype (nnon-case/ncase) | Odds Ratio (95%CI) | p-value | |
| GG (1227/268) | 1 (reference) | ||
| GA+AA (322+23/55+2) | 0.78 (0.54–1.12) | 0.8 | |
| C) | |||
| Genotype (nnon-case/ncase) | Odds Ratio (95%CI) | p-value | |
| GG (621/642) | 1 (reference) | ||
| GA+AA (170+10/202+8) | 1.25 (0.95–1.66) | 0.1 | |
| D) | |||
| Genotype | Mean (±SD) | p-value | |
| D1) | GG | 0.079±0.027 | 0.7 |
| GA+AA | 0.078±0.030 | ||
| D2) | GG | 45.69±30.17 | 0.8 |
| GA+AA | 46.02±30.09 | ||
| D3) | GG | 3.53±1.81 | 0.7 |
| GA+AA | 3.49±1.92 | ||
All models were adjusted for age, gender and BMI, respectively.