Nuclear anchorage is aberrant in desmin knockout mouse myotubes. A skeletal muscle fiber from a desmin knockout mouse is stained with Hoechst to detect nuclei. Arrows indicate areas lacking nuclei and arrowheads mark large nuclear aggregates. One cluster is magnified in the inset. A portion of a wildtype myotube is shown on the left.56 Copyright © 2006, John Wiley & Sons, Inc. Reprinted with premission of Wiley-Liss, Inc., a subsidiary of John Wiley & Sons, inc