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. 2008 Nov 24;205(12):2813–2825. doi: 10.1084/jem.20080938

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© 2008 Jani et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 5. — A model for the roles of Brg in CD4 regulation. T cells develop from DN to DP cells. CD4 expression (red dots), first detected in DN4 cells, is controlled by the silencer (S), CD4 promoter (P), enhancer (E), and LCR (L). For simplicity, the silencer is depicted to be located upstream of, and to act on, the CD4 promoter (top), but the exact mechanism of repression is unknown. Brg plays a dual role in CD4 regulation in DN cells by acting on both the silencer and enhancer/LCR, using distinct biochemical activities (bottom). Brg binds these elements, but it remains to be seen whether this interaction is functionally relevant.