Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2008 Nov 24;205(12):2791–2801. doi: 10.1084/jem.20080767

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2008 Chen et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 6. — Mycobacterial burden of PGES^−/− and WT Mφ in vitro and in vivo. (A) Mycobacterial burden after 4 h (inoculum), 4 d, and 7 d of PGES^−/− and WT Mφ in vitro infected with H37Rv (MOI 10:1). The difference in the bacterial burden was significant at 4 and 7 d after infection (*, P < 0.03). (B) 5 wk after aerosol infection, CFUs were determined by plating of homogenized lung tissue as indicated on the ordinate. The difference in mycobacterial burden in the lungs of PGES^−/− versus WT mice is statistically significant (*, P = 0.002; five mice per group). (C and D) Induction of LXA₄ and PGE₂ production during the course of mycobacterial infection. WT mice were infected by aerosol exposure with virulent (Erdmann) or avirulent (H37Ra). LXA₄ (C) and PGE₂ (D) measured by ELISA in the sera at 7, 14, and 35 d after infection (*, P < 0.01; three mice per time points). These results are representative of two independent experiments. The error bars represent SE.