Table I.
Retrospective genome-wide mapping of known mHag loci by zygosity-genotype correlation analysis
| mHag | SNP | Frequency (literature) |
Frequency (in 14 trios) |
Number of trios | Useful number of individuals |
Locus: number of r2 = 1 SNPs |
Source |
|---|---|---|---|---|---|---|---|
| % | % | ||||||
| HMSD | rs9945924 | 35.6 | 31 | 11 | 30 | 7 | reference 12 |
| ACC-1Y | rs1138357 | 46.5* | 47.6 | 10 | 23 | 8 | reference 8 |
| ACC-2 | rs3826007 | 44.5* | 47.6 | 10 | 23 | 8 | reference 8 |
| ADIR | rs2296377 | 37 | 42.9 | 13 | 27 | 8 | reference 20 |
| HA-8 | rs2173904 | 70.2* | 64.3 | 10 | 16 | 11 | reference 21 |
| HB-1Y | rs161557 | 46.3* | 14.3 | 14 | 41 | 1 | reference 22 |
Results of the correlation analyses for six mHags. Published phenotype frequencies are derived from Spierings et al. (19; *) or from the indicated reference. Analyses were performed as described in Fig. 4. Depicted is the minimal number of trios (Number of trios) resulting in only a single genome locus with 100% correlation, together with the number of CEPH individuals for whom zygosity data was available (Useful number of individuals). Also depicted is the number of SNPs with 100% correlation that was found at this genome locus (Locus: number of r2 = 1 SNPs).