Skip to main content
. Author manuscript; available in PMC: 2008 Nov 21.
Published in final edited form as: J Stem Cells. 2006;1(2):125–147.

Table 5. Reported associations with MHC and cytokine genes in different ethnic groups.

Gene Finding Population Ref
A1, B8, DR3 Increased in elderly men, decreased T cell function and decreased survival in women. Caucasian, NAm [154]
A1, B8, Cw7, DR3 Increased in Nonagenarian men Caucasian, Ireland [155]
DRB1*1401, DQB1*0503, DQA1*0101 Increased in Centenarians Oriental, Japan [146]
B16 Increased in elderly Greek [147]
DR7 Increased in elderly Greek [147]
B15 Decreased in elderly Greek [147]
DR4 Decreased in elderly Greek [147]
DR11 Increased in elderly women Caucasian, French [156]
DR7 Increased in elderly men Caucasian, French [156]
DR13 Increased in elderly men and women Caucasian, French [156]
A31, B7, Cw7, DQ1 Increased in elderly Caucasian, Italy [157]
A1, B8, DR3, TNF No association Caucasian, Ireland [143]
DRB1*15 Increased in Centenarians Sardinian [148]
HSP70-1 -110A>C Association of heterozygosity in aged twins Caucasian, Danish [158]
TNF -308 A Increased in elderly with bronchoalveolar infections Caucasian, Italy [142]
IL-6-174 C Increased in Centenarian men Sardinian [159]
IFN-γ+874A Increased in centenarian women Sardinian [159]
IL-6-174 G/G Homozygous genotype G/G increased in elderly Caucasian, Denmark [160]
IL-10-1082G/A,-819C/C,-592C/C Increased in elderly Caucasian, Bulgaria [161]
IL-10-1082G Increased in centenarian men Caucasian, Italy [162]
TGF-β1 +915G/C Decreased in centenarians Caucasian, Italy [163]