Table 1.
Baseline clinical and laboratory values (mean +/− SD) of enrolled subjects
| Metformin N = 60 | Placebo N = 25 | P-value | |
|---|---|---|---|
| Age (years) | 15.5 ± 1.7 | 14.2 ± 4.6 | 0.18 |
| Sex (% female) | 43 (72 %) | 17 (68%) | 0.74 |
| Race: Hispanic | 34 (57%) | 14 (52%) | 0.70 |
| Race: AA | 20 (33%) | 9 (36%) | 0.82 |
| Race: Other | 6 (10%) | 2 (8%) | 0.78 |
| Family history T2DM | 55 (92%) | 23 (92%) | NS |
| BMI (kg/m2) | 39.4 ± 6.5 | 39.3 ± 7.2 | 0.95 |
| BMI z-score | 4.6 ± 1.8 | 6.2 ± 8.9 | 0.41 |
| Weight (kg) | 108.8 ± 23.1 | 110.6 ± 23.4 | 0.74 |
| Systolic BP | 130.5 ± 18.7 | 130.3 ± 16.2 | 0.97 |
| Diastolic BP | 69.4 ± 10.6 | 70.1 ± 6.9 | 0.73 |
| Fasting glucose mg/dl | 88.5 ± 11.6 | 88.8 ± 10.0 | 0.91 |
| 2-hour glucose mg/dl | 112.1 ± 22.6 | 110.4 ± 26.4 | 0.77 |
| Fasting Insulin microunits/ml | 35.8 ± 19.4 | 34.4 ± 14.5 | 0.74 |
| 2-hour Insulin microunits/ml | 164.4 ± 119.4 | 163.0 ± 92.4 | 0.96 |
| Fasting triglycerides mg/dl | 148.0 ± 84.8 | 138.5 ± 58.2 | 0.61 |
| IFG only # (%) | 5 (8.3%) | 2 (6.7%) | 0.96 |
| IGT only # (%) | 5 (8.3%) | 2 (6.7%) | 0.96 |
| IFG and IGT # (%) | 2 (3.3%) | 1 (4%) | 0.88 |