Figure 5.
β2-stimulation (zinterol + CGP) increases SERCA, but does not alter NCX in HF rabbit myocytes (or either in control). A) Superimposed normalized 1 Hz Ca transients at baseline and with β2-AR show no difference in control rabbit myocytes (left) but decline faster with zinterol +CGP in HF rabbit myocytes (right). B) Superimposed normalized caffeine-induced Ca transient ± zinterol +CGP show similar decay in control (left) and HF (right) rabbit myocytes. C) Mean values of exponential decay (τ) of twitch Ca transients and caffeine-induced Ca transients at baseline and with zinterol + CGP in nonfailing rabbit myocyte (left, n=11) and HF rabbit myocytes (right, n=12). * denotes p < 0.05.