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Comparison of the effects of isopimpinellin on PXR and SXR activation in transfected cells
| GAL-PXR | ED50 (nM) | Max (nM) | GAL-SXR | ED50 (nM) | Max (nM) |
|---|---|---|---|---|---|
| PCN (+) | 63 | 3,000 | RIF (+) | 1,259 | 10,000 |
| Isopimp. | 17,783 | 100,000 | Isopimp. | 35,481 | 100,000 |
| PXR-DR3 | ED50 (nM) | Max (nM) | SXR-DR3 | ED50 (nM) | Max (nM) |
|
| |||||
| PCN (+) | 20 | 100 | RIF (+) | 2,512 | 10,000 |
| Isopimp. | 15,849 | 30,000 | Isopimp. | 39,811 | 100,000 |
