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. Author manuscript; available in PMC: 2009 Oct 15.
Published in final edited form as: Toxicol Appl Pharmacol. 2008 Jul 15;232(2):337–350. doi: 10.1016/j.taap.2008.07.004

Table 1.

Comparison of the effects of isopimpinellin on PXR and SXR activation in transfected cells

GAL-PXR ED50 (nM) Max (nM) GAL-SXR ED50 (nM) Max (nM)
PCN (+) 63 3,000 RIF (+) 1,259 10,000
Isopimp. 17,783 100,000 Isopimp. 35,481 100,000
PXR-DR3 ED50 (nM) Max (nM) SXR-DR3 ED50 (nM) Max (nM)

PCN (+) 20 100 RIF (+) 2,512 10,000
Isopimp. 15,849 30,000 Isopimp. 39,811 100,000