Skip to main content
. Author manuscript; available in PMC: 2008 Nov 21.
Published in final edited form as: J Am Chem Soc. 2006 May 10;128(18):6054–6055. doi: 10.1021/ja061105q

Table 1.

Selected Optimization studies:

Entry Pd source (mol%) Cs2CO3(eq.) Conc.(M) Yield(%)a ee(%)b
1 Pd2(dba)3CHCl3(5) 1.0 0.02 90 84
2 Pd2(dba)3CHCl3(5) 0.7 0.02 75 92
3 Pd2(dba)3CHCl3(2.5) 1.0 0.02 89 66
4 Pd2(dba)3CHCl3(1.25) 1.0 0.08 75 85
5 [Pd(C3H5)Cl]2(2) 1.0 0.17 88–93 87
6 [Pd(C3H5)Cl]2(1.25) 1.0 0.08 83 92
a

Isolated yield.

b

Enantioselectivities were determined by chiral HPLC.