Figure 1.
Pulmonary histopathology and inflammation. Mice were killed 14 days after saline or bleomycin exposure, and the lungs were lavaged and processed for hematoxylin and eosin staining. (A) Lung section from an A3R+/+ mouse exposed to saline. (B) Lung section from an A3R−/− mouse exposed to saline. (C) Lung section from an A3R+/+ mouse exposed to bleomycin. (D) Lung section from an A3R−/− mouse exposed to bleomycin. Photographs are representative of six to eight mice from each condition; scale bars = 100 μm. (E) Total bronchoalveolar lavage (BAL) cell counts presented as mean cell counts × 104 ± SEM. *Significant difference compared with saline treatment, #significant difference compared with bleomycin-treated A3R+/+ mice (P < 0.05, n = 6–8).