TABLE 1.
GENES ALTERED IN THEIR EXPRESSION BY HHV-8 INFECTION OF POTENTIAL INTEREST IN THE PATHOPHYSIOLOGY OF PULMONARY HYPERTENSION
| Gene | Gene Symbol | Fold Change in HHV-8 Infection | Cellular Function/Pathway |
|---|---|---|---|
| Bone morphogenic protein receptor-1a | BMPR1a | 0.5 | TGF-β pathway |
| Bone morphogenic protein 4 | BMP4 | 0.6 | TGF-β pathway |
| Noggin | Nog | 22.6 | TGF-β pathway |
| Interleukin-6 | IL-6 | 5.7 | Inflammation/immunity |
| Matrix metalloproteinase-1 | MMP-1 | 73 | Peptidase/ECM remodeling |
| Matrix metalloproteinase-2 | MMP-2 | 1.4 | Peptidase/ECM remodeling |
| Matrix metalloproteinase-10 | MMP-10 | 5.3 | Peptidase/ECM remodeling |
| Platelet derived growth factor D | PDGFD | 0.5 | Growth factor |
| Fms-Related Tyrosine Kinase-1 | FLT-1 | 6.9 | Angiogenesis |
| Angiopoietin 2 | ANGPT12 | 5.1 | Angiogenesis |
Definition of abbreviations: ECM, extracellular matrix; HHV-8, human herpesvirus-8.
Relative fold change of gene expression of HHV-8–infected cells as compared to mock-infected cells is listed.