TABLE 3.
EXPRESSION OF APOPTOTIC CELL REMOVAL RECEPTOR GENES IN ALVEOLAR MACROPHAGES OF NORMAL SMOKERS COMPARED TO NORMAL NONSMOKERS
| Probe Set ID | Gene Symbol | Gene Title | Nonsmoker, % Present | Smoker, % Present | Smoker/Nonsmoker | P Value |
|---|---|---|---|---|---|---|
| 205786_s_at | CR3 | Complement component receptor 3 | 100 | 100 | 1.31 | 0.231 |
| 210184_at | CR4 | Complement component receptor 4 | 100 | 100 | 1.36 | 0.112 |
| 201743_at | CD14 | CD14 | 100 | 100 | −1.86 | 0.003 |
| 208981_at | CD31 | CD31 | 100 | 100 | −1.01 | 0.946 |
| 206488_s_at | CD36 | CD36 (thrombospondin receptor) | 100 | 100 | 1.24 | 0.363 |
| 1565868_at | CD44 | CD44 | 100 | 100 | 1.73 | 0.142 |
| 202878_s_at | CD93 | CD93 | 82 | 100 | −1.01 | 0.932 |
| 232797_at | ITGAV | Integrin, α V (vitronectin receptor) | 100 | 100 | −1.08 | 0.724 |
| 200784_s_at | LRP | Low-density lipoprotein–related protein (α-2-macroglobulin receptor) | 100 | 100 | 1.18 | 0.494 |
| 242397_at | OLR1 | Oxidized low density lipoprotein receptor | 100 | 100 | −1.46 | 0.081 |
| 206028_s_at | MERTK | c-Mer protooncogene tyrosine kinase | 64 | 100 | 3.60 | 0.003 |
| 214770_at | MSR1 | Macrophage scavenger receptor 1 | 100 | 100 | −1.04 | 0.768 |
| 212723_at | PTDSR | Phosphatidylserine receptor | 100 | 100 | 1.05 | 0.594 |
| 205216_s_at | APOH | β2-glycoprotein I | 0 | 0 | — | — |
Expression was assessed by Affymetrix HG U133 Plus 2.0 microarray; listed are all apoptotic cell removal receptor genes considered “expressed” based on the criteria of % present in ≥ 50% samples of either normal nonsmokers or normal smokers. MERTK (in boldface) was the only apoptotic receptor most significantly up-regulated in smokers compared with nonsmokers.