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. Author manuscript; available in PMC: 2009 Oct 3.
Published in final edited form as: Brain Res. 2008 Jul 25;1233:129–136. doi: 10.1016/j.brainres.2008.07.057

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Effect of selective nicotinic antagonists on olanzapine-induced changes in sensory inhibition. The effect of olanzapine was assessed alone and after preadministration of either α-bungarotoxin (α-BTX, an α7 nicotinic receptor antagonist) or di-hydro-β-erythroidine (DHβE, an α4β2 nicotinic receptor antagonist). (A) Representative waveforms from 3 DBA/2 mice show that pretreatment with α-BTX blocked the olanzapine-induced normalization of the deficient sensory inhibition of the P20-N40 AEP while administration of DHβE did not. Tick marks note the P20-N40 waveform. Calibration: 50 ms by 25 µV. (B) Comparison of the average TC ratios from the 15 minutes before and after olanzapine administration shows a significant decrease in TC ratio only after olanzapine or olanzapine plus DHβE. Administration of the α7 nicotinic receptor antagonist α-BTX prevents the olanzapine-induced improvement. n=8 for olanzapine, n=4 for DHβE, n=7 for α-BTX. *p<0.05, Student’s t-test.