Table 2.
Comparison of Metabolite Ratios by Genotype in all ROIs
| Region | Val/Val | Val/Met | Statistic | P |
|---|---|---|---|---|
| Left Hippocampus | n=38 | n=12 | ||
| NAA/Cre | 1.82(±0.21) | 1.68(±0.20) | F(1,46)=5.01 | p=0.03† |
| Effect of Age | 28.9(±9.17) | 34.3(±11.5) | F(1,46)=7.71 | p=0.007 |
| Effect of IQ | 107(±9.9) | 113(±7.1) | F(1,46)= 1.40 | p=0.24 |
| NAA/Cho | 1.25(±0.14) | 1.15(±0.09) | F(1,46)=7.40 | p=0.009† |
| Effect of Age | 28.9(±9.17) | 34.3(±11.5) | F(1,46)=4.64 | p=0.04 |
| Effect of IQ | 107(±9.9) | 113(±7.1) | F(1,46)=0.02 | p=0.89 |
| Cho/Cre | 1.46(±0.16) | 1.46(±0.19) | F(1,47)=0.002 | p=0.78ˆ |
| Right Hippocampus | n=39 | n=12 | ||
| NAA/Cre | 1.80(±0.22) | 1.80(±0.23) | F(1,48)=0.17 | p=0.69ˆ |
| NAA/Cho | 1.28(±0.18) | 1.24(±0.15) | F(1,48)=1.40 | p=0.24ˆ |
| Cho/Cre | 1.41(±0.16) | 1.46(±0.15) | F(1,48)=2.72 | p=0.11ˆ |
| Occipital Cortex | n=44 | n=15 | ||
| NAA/Cre | 2.19(±0.19) | 2.17(±0.16) | F(57)=0.13 | p=0.72 |
| NAA/Cho | 2.21(±0.29) | 2.26(±0.26) | F(57)=0.36 | p=0.55 |
| Cho/Cre | 1.00(±0.12) | 0.97(±0.14) | F(57)=0.64 | p=0.43 |
| Left dlPFC | n=45 | n=15 | ||
| NAA/Cre | 2.22(±0.20) | 2.11(±0.22) | F(1,57)=1.53 | p=0.22* |
| NAA/Cho | 2.12(±0.20) | 2.07(±0.24) | F(1,57)=0.001 | p=0.97* |
| Cho/Cre | 1.05(±0.11) | 1.03(±0.11) | F(58)=0.70 | p=0.41 |
| Right dlPFC | n=45 | n=16 | ||
| NAA/Cre | 2.23(±0.18) | 2.24(±0.20) | F(58)=0.86 | p=0.36* |
| NAA/Cho | 2.14(±0.22) | 2.11(±0.23) | F(58)=0.21 | p=0.65* |
| Cho/Cre | 1.05(±0.09) | 1.07(±0.14) | F(59)=0.57 | p=0.45 |
| Anterior Cingulate | n=44 | n=15 | ||
| NAA/Cre | 2.02(±0.15) | 1.97(±0.13) | F(1,56)=1.16 | p=0.69* |
| NAA/Cho | 1.49(±0.20) | 1.45(±0.17) | F(1,56)=0.01 | p=0.92* |
| Cho/Cre | 1.37(±0.14) | 1.38(±0.18) | F(57)=0.55 | p=0.46 |
| White Matter | n=45 | n=14 | ||
| NAA/Cre | 2.57(±0.22) | 2.46(±0.20) | F(1,56)=1.43 | p=0.24* |
| NAA/Cho | 1.98(±0.24) | 1.92(±0.17) | F(1,56)=0.51 | p=0.48* |
| Cho/Cre | 1.31(±0.14) | 1.29(±0.11) | F(57)=0.42 | p=0.52 |
Abreviations: dlPFC, dorsolateral prefrontal cortex
Data are presented as mean±SD in parentheses
†
Age and IQ used as covariates in the ANCOVA
ˆ
IQ used as a covariate in the ANCOVA
*
Age used as a covariate in the ANCOVA