Figure 2. DHEA sulfation by intact T-47D cells.
The T-47D cells were washed twice with PBS then placed in serum-free RPMI1640 without phenol-red in 6 well plates. [3H]-DHEA was added to the medium to a final concentration of 3 µM. The formation of [3H]-DHEA-sulfate was determined in aliquots of the medium by scintillation counting after chloroform extraction to remove unsulfated [3H]-DHEA. DHEA sulfation is expressed as pmol/mg protein. The standard derivation of the [3H]-DHEA-sulfate determinations are included within the points.
