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. Author manuscript; available in PMC: 2009 Jul 15.
Published in final edited form as: Toxicol Appl Pharmacol. 2008 Mar 6;230(2):167–174. doi: 10.1016/j.taap.2008.02.024

Fig. 8.

Fig. 8

Metal transport by MTP1, DMT1 and TfR in choroidal epithelial cells. Under physiological condition, DMT1 takes up Mn or Fe from the CSF, while MTP1 expels metals to the CSF. Upon metal exposure from the CSF, the uptake of metals by apical DMT1 increases intracellular metal concentrations. MTP1, in response, moves toward apical microvilli, expelling metal ions back to the CSF. Elevated Mn concentration enhances the translational expression of TfR, leading to a TfR-mediated transport of transferrin-bound metals including Fe to the CSF.