Abstract
Pasteurella haemolytica A1 crude leukotoxin (25%, vol/vol) rapidly diminished the bovine neutrophil chemiluminescence response to opsonized zymosan. This inhibition was neither prevented nor reversed by 75 mM sucrose. Dilute leukotoxin did not directly stimulate neutrophil chemiluminescence nor did it alter the chemiluminescence response of the neutrophils to opsonized zymosan.
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Selected References
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- Baluyut C. S., Simonson R. R., Bemrick W. J., Maheswaran S. K. Interaction of Pasteurella haemolytica with bovine neutrophils: identification and partial characterization of a cytotoxin. Am J Vet Res. 1981 Nov;42(11):1920–1926. [PubMed] [Google Scholar]
- Berggren K. A., Baluyut C. S., Simonson R. R., Bemrick W. J., Maheswaran S. K. Cytotoxic effects of Pasteurella haemolytica on bovine neutrophils. Am J Vet Res. 1981 Aug;42(8):1383–1388. [PubMed] [Google Scholar]
- Bhakdi S., Greulich S., Muhly M., Eberspächer B., Becker H., Thiele A., Hugo F. Potent leukocidal action of Escherichia coli hemolysin mediated by permeabilization of target cell membranes. J Exp Med. 1989 Mar 1;169(3):737–754. doi: 10.1084/jem.169.3.737. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Breider M. A., Walker R. D., Hopkins F. M., Schultz T. W., Bowersock T. L. Pulmonary lesions induced by Pasteurella haemolytica in neutrophil sufficient and neutrophil deficient calves. Can J Vet Res. 1988 Apr;52(2):205–209. [PMC free article] [PubMed] [Google Scholar]
- Cavalieri S. J., Snyder I. S. Effect of Escherichia coli alpha-hemolysin on human peripheral leukocyte function in vitro. Infect Immun. 1982 Sep;37(3):966–974. doi: 10.1128/iai.37.3.966-974.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chang Y. F., Renshaw H. W., Augustine J. L. Bovine pneumonic pasteurellosis: chemiluminescent response of bovine peripheral blood leukocytes to living and killed Pasteurella haemolytica, Pasteurella multocida, and Escherichia coli. Am J Vet Res. 1985 Nov;46(11):2266–2271. [PubMed] [Google Scholar]
- Chang Y. F., Renshaw H. W. Pasteurella haemolytica leukotoxin: comparison of 51chromium-release, trypan blue dye exclusion, and luminol-dependent chemiluminescence-inhibition assays for sensitivity in detecting leukotoxin activity. Am J Vet Res. 1986 Jan;47(1):134–138. [PubMed] [Google Scholar]
- Clinkenbeard K. D., Mosier D. A., Confer A. W. Transmembrane pore size and role of cell swelling in cytotoxicity caused by Pasteurella haemolytica leukotoxin. Infect Immun. 1989 Feb;57(2):420–425. doi: 10.1128/iai.57.2.420-425.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Czuprynski C. J., Hamilton H. L., Noel E. J. Ingestion and killing of Pasteurella haemolytica A1 by bovine neutrophils in vitro. Vet Microbiol. 1987 May;14(1):61–74. doi: 10.1016/0378-1135(87)90053-8. [DOI] [PubMed] [Google Scholar]
- Gentry M. J., Confer A. W., Weinberg E. D., Homer J. T. Cytotoxin (leukotoxin) production by Pasteurella haemolytica: requirement for an iron-containing compound. Am J Vet Res. 1986 Sep;47(9):1919–1923. [PubMed] [Google Scholar]
- Greer C. N., Shewen P. E. Automated colorimetric assay for the detection of Pasteurella haemolytica leucotoxin. Vet Microbiol. 1986 Jun;12(1):33–42. doi: 10.1016/0378-1135(86)90039-8. [DOI] [PubMed] [Google Scholar]
- Noel E. J., Israel B. A., Letchworth G. J., 3rd, Czuprynski C. J. Preincubation of bovine blood neutrophils with bovine herpesvirus-1 does not impair neutrophil interaction with Pasteurella haemolytica A1 in vitro. Vet Immunol Immunopathol. 1988 Oct;19(3-4):273–284. doi: 10.1016/0165-2427(88)90114-6. [DOI] [PubMed] [Google Scholar]
- Shewen P. E., Wilkie B. N. Cytotoxin of Pasteurella haemolytica acting on bovine leukocytes. Infect Immun. 1982 Jan;35(1):91–94. doi: 10.1128/iai.35.1.91-94.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Slocombe R. F., Malark J., Ingersoll R., Derksen F. J., Robinson N. E. Importance of neutrophils in the pathogenesis of acute pneumonic pasteurellosis in calves. Am J Vet Res. 1985 Nov;46(11):2253–2258. [PubMed] [Google Scholar]
- Strathdee C. A., Lo R. Y. Extensive homology between the leukotoxin of Pasteurella haemolytica A1 and the alpha-hemolysin of Escherichia coli. Infect Immun. 1987 Dec;55(12):3233–3236. doi: 10.1128/iai.55.12.3233-3236.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]