TABLE 3.
Conservation of residue pairs in the six ASIC subtypes based on sequence comparison data (14)
| Subtype | D238:D350 | E239:D346 | E220:D408 | E80:E417 | E339:E343 | D132:E133 | D127:E236 | E299:D332 | D290:E363 | E451:D454 |
|---|---|---|---|---|---|---|---|---|---|---|
| ASIC1a | C | C | C | C | C | C | C | C | C | C |
| ASIC1b | C | C | C | C | C | C | N | C | C | C |
| ASIC2a | n | C | C | C | C | n | C | C | n | C |
| ASIC2b | n | C | C | n | C | C | C | C | n | C |
| ASIC3 | C | n | C | C | n | n | N | n | n | C |
| ASIC4 | n | C | C | C | n | n | N | n | n | C |
If both residues in a pair are conserved, the pair is designated by “C” (conserved), whereas if any one residue of the pair is not conserved, the pair is designated as “n” (not conserved).