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. 2008 Dec 12;4(12):e1000300. doi: 10.1371/journal.pgen.1000300

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Ferullo, Lovett.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Wild type cells in M9 Glucose CAA medium were treated with serine hydroxamate for 1.5 h as previously described. Cells were then washed of serine hydroxamate, incubated in fresh medium, and samples were taken for flow cytometric analysis for DNA content and DAPI staining as previously described. (A) DNA content histograms and (B) corresponding fluorescent DAPI images of cultures incubated with serine hydroxamate for 1.5 h and of cultures at 15, 30, and 60 min after being released from serine hydroxamate. (C) Model for chromosome segregation patterns for 4N cells released from stringent arrest. Cohesion of sister chromosomes help enforce the sequence of segregation of chromosomes from the single nucleoid mass. Pairs of sister chromosomes held in cohesion at their termini segregate first at midcell. After release of cohesion, sisters separate at ¼ positions.