Table 4. Sex-specific liver genes belonging to groups 13A and 13B, which are up- or down-regulated in STAT5a-deficient females but not males and whose sex-specificity is lost in the STAT5a-knockout strain.
Top, shown are the 26 male-specific genes representing group 13A. Bottom, shown are the top 26 female-specific genes representing group 13B. MMT accession numbers are identification numbers assigned to probes that could not be linked to a specific GenBank accession number. Expression ratios shown are average values based on 3 independent microarrays, each carried out in duplicate (dye swap). Individual gene data for all other members of group 13B, and for all other groups listed in Table 3, are presented in Table S2. Values shown in bold are significant by P-value.
| Expression Ratio (average) | ||||||
|---|---|---|---|---|---|---|
| RefSeq/GenBank ID | Common Name(s) | Description | M-WT: F-WT | M-WT: M-KO | F-KO: F-WT | F-KO: M-KO |
| Group 13A. Male predominant and increased in STAT5a-deficient females (total of 26 genes) | ||||||
| NM_146245 | Lrrc21 | leucine rich repeat containing 21 | 3.34 | 0.60 | 4.76 | 0.79 |
| NM_027907 | Agxt2l1 | alanine-glyoxylate aminotransferase 2-like 1 | 3.55 | 0.81 | 3.12 | 0.70 |
| NM_198967 | Tmtc1 | Transmembrane and tetratricopeptide repeat containing 1 | 2.73 | 0.93 | 2.72 | 0.91 |
| NM_025308 | 1810007E14Rik | hypothetical protein LOC53906 | 2.85 | 1.23 | 2.66 | 0.78 |
| MMT00033789 | MMT00033789 | Similar to serine (or cysteine) proteinase inhibitor, clade A, | 2.34 | 1.09 | 2.23 | 1.02 |
| NM_010406 | Hc | hemolytic complement | 3.44 | 2.02 | 2.11 | 1.45 |
| NM_020581 | Angptl4 | angiopoietin-like 4 | 2.18 | 0.82 | 2.06 | 0.74 |
| MMT00033197 | MMT00033197 | Similar to serine (or cysteine) proteinase inhibitor, clade A, | 2.15 | 1.09 | 1.99 | 1.00 |
| NM_008458 | Serpina3c | serine (or cysteine) proteinase inhibitor, clade A, member 3C | 2.00 | 0.86 | 1.96 | 0.79 |
| NM_019748 | Sae1 | SUMO1 activating enzyme subunit 1 | 2.12 | 1.06 | 1.76 | 0.88 |
| NM_145743 | Lace1 | lactation elevated 1 | 1.96 | 0.97 | 1.74 | 0.87 |
| NM_010012 | Cyp8b1 | cytochrome P450, family 8, subfamily b, polypeptide 1 | 2.47 | 1.08 | 1.74 | 0.70 |
| NM_025576 | Ptpmt1 | Protein tyrosine phosphatase, mitochondrial 1 | 1.83 | 1.30 | 1.60 | 1.14 |
| NM_145940 | Wipi1 | WD repeat domain, phosphoinositide interacting 1 | 1.70 | 0.83 | 1.59 | 0.78 |
| NM_172142 | IkappaBNS | NF-kappa B inhibitor | 1.66 | 1.05 | 1.51 | 0.96 |
| NM_134112 | Kctd1 | Potassium channel tetramerisation domain containing 1 | 1.75 | 1.05 | 1.44 | 0.80 |
| NM_019823 | Cyp2d22 | cytochrome P450, family 2, subfamily d, polypeptide 22 | 1.66 | 0.92 | 1.43 | 0.76 |
| NM_133902 | Sds1 | Serine dehydratase-like | 1.53 | 0.94 | 1.40 | 0.83 |
| NM_019911 | Tdo2 | tryptophan 2,3-dioxygenase | 2.08 | 1.05 | 1.39 | 0.82 |
| NM_008391 | Irf2 | interferon regulatory factor 2 | 1.56 | 0.99 | 1.36 | 0.94 |
| NM_001040700 | BC051019 | RefSeq Gene BC051019 | 1.74 | 1.07 | 1.34 | 0.82 |
| NM_172479 | Slc38a5 | Solute carrier family 38, member 5 | 1.53 | 1.01 | 1.34 | 0.92 |
| NM_133906 | Zkscan1 | Zinc finger with KRAB and SCAN domains 1 | 1.60 | 1.23 | 1.30 | 1.01 |
| NM_145365 | Creb3l3 | cAMP responsive element binding protein 3-like 3 | 1.53 | 0.99 | 1.30 | 0.83 |
| NM_008933 | Prm2 | protamine 2 | 1.69 | 1.06 | 1.27 | 0.85 |
| NM_009255 | Serpine2 | serine (or cysteine) proteinase inhibitor, clade E, member 2 | 1.51 | 1.08 | 1.27 | 0.85 |
| Group 13B. Female predominant and decreased in STAT5a-deficient females (total of 164 genes) | ||||||
| NM_175270 | Ankrd56 | Ankrd56 ankyrin repeat domain 56 | 0.27 | 0.76 | 0.13 | 0.40 |
| NM_010766 | Marco | macrophage receptor with collagenous structure | 0.27 | 0.36 | 0.19 | 0.32 |
| NM_007836 | Gadd45a | growth arrest and DNA-damage-inducible 45 alpha | 0.25 | 1.07 | 0.19 | 0.89 |
| NM_010654 | Klrd1 | killer cell lectin-like receptor, subfamily D, member 1 | 0.10 | 1.17 | 0.28 | 1.34 |
| NM_008321 | Idb3 | inhibitor of DNA binding 3 | 0.39 | 0.71 | 0.29 | 0.56 |
| NM_019467 | Aif1 | allograft inflammatory factor 1 | 0.38 | 0.78 | 0.32 | 0.68 |
| NM_011087 | Pira1 | paired-Ig-like receptor A1 | 0.31 | 0.85 | 0.32 | 0.98 |
| NM_020008 | Clec7a | C-type lectin, family 7, member a | 0.40 | 0.93 | 0.34 | 0.85 |
| NM_021272 | Fabp7 | fatty acid binding protein 7, brain | 0.39 | 0.98 | 0.36 | 0.90 |
| NM_010496 | Idb2 | inhibitor of DNA binding 2 | 0.44 | 0.90 | 0.36 | 0.75 |
| NM_010724 | Psmb8 | proteosome subunit, beta type 8 (large multifunctional protease | 0.31 | 0.62 | 0.37 | 0.77 |
| NM_010531 | Il18bp | interleukin 18 binding protein | 0.33 | 0.63 | 0.37 | 0.82 |
| NM_008527 | Klrb1c | killer cell lectin-like receptor subfamily B member 1C | 0.49 | 0.94 | 0.37 | 0.99 |
| BC013712 | BC013712 | basement membrane-induced protein | 0.38 | 0.78 | 0.37 | 0.77 |
| NM_026268 | Dusp6 | dual specificity phosphatase 6 | 0.29 | 1.58 | 0.38 | 2.05 |
| NM_019494 | Cxcl11 | chemokine (C-X-C motif) ligand 11 | 0.45 | 0.84 | 0.39 | 0.90 |
| NM_029620 | Pcolce2 | procollagen C-endopeptidase enhancer 2 | 0.35 | 0.73 | 0.40 | 0.82 |
| NM_010407 | Hck | hemopoietic cell kinase | 0.47 | 0.82 | 0.40 | 0.72 |
| NM_010370 | Gzma | granzyme A | 0.49 | 1.20 | 0.41 | 1.15 |
| NM_178933 | Ostb | organic solute transporter beta | 0.57 | 1.15 | 0.41 | 0.80 |
| NM_030060 | 9130211I03Rik | Jun dimerization protein p21SNFT | 0.35 | 0.83 | 0.41 | 1.10 |
| AF065902 | Itgal | integrin alpha L | 0.37 | 0.99 | 0.41 | 1.21 |
| NM_178759 | Timd4 | T-cell immunoglobulin and mucin domain containing 4 | 0.22 | 0.65 | 0.41 | 1.23 |
| NM_144559 | Fcrl3 | Fc receptor-like 3 | 0.41 | 0.91 | 0.42 | 1.04 |
| NM_172659 | Slc2a6 | solute carrier family 2 (facilitated glucose transporter), member | 0.51 | 0.84 | 0.42 | 0.73 |
| BI407225 | Hk3 | hexokinase 3 | 0.44 | 0.83 | 0.42 | 0.81 |