Figure 2.

Tumor-free survival of Brca1-deficient females that lack 60 cM of chromosome 11 (MMTV-Cre Brca1^fl/fl Wap^wt/neo, n = 12, and WAP-Cre Brca1^fl/fl Wap^neo/neo, n = 7) in comparison to Brca1 conditional knockout mice (MMTV-Cre Brca1^fl/fl, n = 17, and WAP-Cre Brca1^fl/fl, n = 15). Mice were monitored twice weekly for a period of 18 months and killed when a tumor became palpable. (A, C) Kaplan-Meier curves. (B, D) Mean age of onset of palpable mammary tumors (horizontal bars). Each marker represents the age of onset of the first palpable tumor per mouse.