Table 2.

Summary of the Mutational Analysis and Immunohistochemistry in OSC Tissues.

Tumor ID	Clinical Data			ROMA-NF1 Deletions	NF1 Mutations Type	pMAPK (IHC)	p53 (IHC)	TP53Mutations (Exon 3–10)				KRAS Exon 2,3	BRAFExon 11,15
	Age	Stage	Grade					Exon	Nucleotide	Codon	Type
OSC-1	83	3C	3	homo	Deletion	+++	+	8	G824A	C275Y	Missense	WT	WT
OSC-2	61	4	3	hemi	Splicing	++	+	5	A395G	K132R	Missense	WT	WT
OSC-3	43	3C	3		WT	-	+	7	A701G	Y234C	Missense	WT	WT
OSC-4	66	3C	3		WT	-	-				WT	WT	WT
OSC-5	58	3B	2	hemi	Deletion	+++	+	5	C380T	S127F	Missense	WT	WT
OSC-6	57	3C	2		WT	++	-				WT	WT	WT
OSC-7	44	3C	3		WT	-	-				WT	WT	WT
OSC-8	57	3C	3		WT	+++	+	5	A491G	K164E	Missense	WT	WT
OSC-9	67	1C	3		WT	+++	+	5	T537G	H179Q	Missense	WT	WT
OSC-10	53	2C	2		WT	ND	+	5	A395G	K132R	Missense	WT	WT
OSC-11	60	4	2	homo	Deletion	+++	+	4	C215G	P72R	Missense	WT	WT
OSC-12	44	3D	3		WT	-	+	9	G976T	E326stop	Nonsense	WT	WT
OSC-13	67	4	1		WT	-	+	5	A395G	K132R	Missense	WT	WT
OSC-14	40	3C	2		WT	++	-	5	C499T	Q167stop	Nonsense	WT	WT
OSC-15	74	3C	3		WT	+	-	5	C497G	S166stop	Nonsense	WT	WT
OSC-16	67	3C	3		WT	++	+	6	C569T	P190L	Missense	WT	WT
OSC-17	62	3C	3		WT	+	-				WT	WT	WT
OSC-18	59	1A	2		Splicing	+++	-	7	746delG	344stop	Frameshift	WT	WT
OSC-19	52	3	3		WT	ND	ND	7	C742T	R248W	Missense	WT	WT
OSC-20	65	2	3		WT	+++	+	7	C725T	C242F	Missense	WT	WT
OSC-21	19	4	1		WT	-	-				WT	WT	WT
OSC-22	30	4	1		WT	-	-				WT	WT	WT
OSC-23	58	3C	2		WT	-	-	8	C916T	R306Stop	Nonsense	WT	WT
OSC-24	53	3C	2	hemi	Deletion/splicing	-	+	8	C817G	R273G	Missense	WT	WT
OSC-25	58	3C	3	hemi	Splicing	+++	+	8	C844T	R282W	Missense	WT	WT
OSC-26	73	3C	2		WT	-	+	8	C844T	R282W	Missense	WT	WT
OSC-27	41	1C	2		WT	ND	-	7	689delC	246stop	Frameshift	WT	WT
OSC-28	61	2C	1		WT	-	-	6	C637T	R213Stop	Nonsense	WT	WT
OSC-29	49	3C	1		WT	++	-				WT	G12R	WT
OSC-30	42	3C	3		WT	+++	-				WT	WT	WT
OSC-31	50	3C	2		WT	-	-				WT	WT	WT
OSC-32	54	3C	3		Splicing	+++	+	5	G517A	V173M	Missense	WT	WT
OSC-33	60	3C	3		WT	-	-	6	C637T	R213Stop	Nonsense	WT	WT
OSC-34	61	3	1		WT	+++	-				WT	WT	WT
OSC-35	43	3C	3		Splicing	+++	+	6	A659G	Y220C	Missense	WT	WT
OSC-36	56	4	3		WT	-	+	6	A659G	Y220C	Missense	WT	ND
OSC-37	48	3C	3		WT	++	+	6	T581G	L194R	Missense	WT	WT
OSC-38	68	1A	3		WT	-	-	7	689delC	246stop	Frameshift	WT	WT
OSC-39	32	1B	1		WT	++	-				WT	WT	WT
OSC-40	68	3C	3		WT	++	-	5	455delC	169stop	Frameshift	WT	WT
OSC-41	73	3C	3		WT	-	+	8	G796A	G266R	Missense	WT	WT