Figure 2.

Slit2 inhibits tumor growth. (A) Slit2 transfection inhibits colony formation of HT1080 and A431 cells in soft agar cultures. In the assessment of tumor growth in vivo, tumor cells were injected subcutaneously in athymic nude mice, and tumor growth was monitored. Transfection with Slit2 suppresses tumor growth of HT1080 (B) and A431 (C). Tumor volume is calculated as length x width x height x 0.63. Data are shown as mean ± SEM of four to five mice per group. *P < .05.