Figure 5.

Slit2 inhibits tumor metastasis in lungs. Athymic mice were injected intravenously with HT1080 tumor cells and lungs were harvested 4 to 5 weeks later for the assessment of tumor metastasis. Paraffin-embedded lung sections were stained with H&E. Tumor nodules were evaluated microscopically. (A) Incidence of mice with metastatic tumors in lungs. Data indicate the percentage of mice with metastatic tumor nodules in lungs (eight mice per group). (B) The number of metastatic tumor nodules per section was counted microscopically. Analysis of data is based on 24 sections per group (mean ± SEM). **P < .01 compared to both control groups. (C) Size of metastatic tumor nodules in lungs. Data indicate the average size (diameter) of tumor nodules of eight mice (mean ± SEM). *P < .05 compared to the size of tumor nodules in lungs of mice injected with control vector-transfected cells.