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. Author manuscript; available in PMC: 2009 Dec 5.
Published in final edited form as: Biochem Biophys Res Commun. 2008 Oct 9;377(1):236–241. doi: 10.1016/j.bbrc.2008.09.130

Fig. 1.

Fig. 1

SNM1A is required for the IR-induced G1 phase cell cycle checkpoint. (A) Western blot shows the depletion of SNM1A in HT-1080 cells 48 hours after siRNA transfection (right panel). FACS analysis of siRNA-transfected HT-1080 cells with or without exposure to IR (3 Gy). (B) Spontaneously immortalized Snm1A MEFs were examined as described in A. (C) Graph represents the ratio of untreated BrdU positive cells to IR treated BrdU positive cells shown in A and B. MEF cell lines #1, #2, and #3 represent three independently derived clones from Snm1A+/+ or Snm1A-/- embryos.