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. Author manuscript; available in PMC: 2009 Jul 11.
Published in final edited form as: Mol Cell. 2008 Jul 11;31(1):21–32. doi: 10.1016/j.molcel.2008.04.028

Figure 5. Nbs1ΔB/ΔB Chk2−/− and Mre11ATLD1/ATLD1 Chk2−/− double mutants are predisposed to tumorigenesis.

Figure 5

(A) Cohort survival of WT, Mre11ATLD1ATLD1 and Nbs1ΔB/ΔB (*combined n=172, ◆), Chk2−/− (n=41, ▲), Nbs1ΔB/ΔB Chk2−/− (n=66, ■), and Mre11ATLD1ATLD1 Chk2−/− (n=67, ●) is shown on a Kaplan Meier curve. *Individual survival curves, tumor free survival curves, and statistical analysis are included in Supplemental Figure S5, S6, and Table S3.

(B) Animals succumbing to tumors are shown as a percentage of their cohort: tumor free (black), 1 tumor (dark gray), 2 tumors (light gray), more than 2 tumors (white).

(C) Survival of Atm−/− (n=71, ▼) and Atm−/− Chk2−/− (n=19, ◇) cohorts plotted on a Kaplan Meier curve.

(D) The percentage of tumor bearing animals with a specific tumor type is plotted for the indicated genotypes.