Fig. 4.
Mean ± SEM alcohol intake (g/kg) by animals in the alcohol binge group (n = 11; left panel) and supersac intake (ml/kg) by supersac controls (n = 12; right panel) following pretreatment with (a) one of four doses (0, 2, 4, 8 mg/kg) of duloxetine (intraperitoneal injection 40 min prior to drinking session), (b) one of five doses (0, 16, 50, 150, 450 μg/kg) of naltrexone (s.c. injection 30 min prior to drinking session), or (c) one of four doses (0, 5, 10, 20 mg/kg) of MPZP (s.c. injection 60 min prior to drinking session). *P<0.05, **P<0.01 significant difference from vehicle condition.