Table 2. Effects of duloxetine, naltrexone, and MPZP and naltrexone on water intake, total fluid intake, and preference [ethanol/supersac:total (E/S:T)] for sweetened alcohol solution by animals in the operant (experiment 2) alcohol binge group and supersac solution by supersac controls.

	Water intake (ml)	Total fluid (ml)	Preference (E/S:T)
Duloxetine
Alcohol binge drinkers
0 mg/kg	0.88 ± 0.30	3.68 ± 0.47	0.70 ± 0.10
2 mg/kg	0.43 ± 0.18	1.93 ± 0.42**	0.72 ± 0.08
4 mg/kg	0.33 ± 0.16	0.92 ± 0.34**	0.57 ± 0.14
8 mg/kg	0.01 ± 0.01 **	0.03 ± 0.03**	N/A
Supersac controls
0 mg/kg	0.40 ± 0.10	21.30 ± 2.44	0.98 ± 0.00
2 mg/kg	0.08 ± 0.04**	9.84 ± 2.55**	0.99 ± 0.00
4 mg/kg	0.07 ± 0.03**	7.43 ± 2.23**	0.98 ± 0.01
8 mg/kg	0.03 ± 0.02**	0.74 ± 0.39**	0.91 ± 0.06
Naltrexone
Alcohol binge drinkers
0 μg/kg	1.30 ± 0.34	3.91 ± 0.36	0.68 ± 0.08
16 μg/kg	1.29 ± 0.27	4.17 ± 0.54	0.67 ± 0.06
50 μg/kg	1.33 ± 0.38	3.45 ± 0.42	0.63 ± 0.08
150 μg/kg	1.12 ± 0.33	3.15 ± 0.41	0.66 ± 0.08
450 μg/kg	0.93 ± 0.25	2.42 ± 0.34**	0.62 ± 0.07
Supersac controls
0 μg/kg	0.22 ± 0.10	19.23 ± 2.30	0.99 ± 0.01
16 μg/kg	0.23 ± 0.13	19.13 ± 1.43	0.98 ± 0.01
50 μg/kg	0.09 ± 0.04	16.87 ± 1.70	1.00 ± 0.00
150 μg/kg	0.24 ± 0.12	16.05 ± 1.93	0.98 ± 0.01
450 μg/kg	0.14 ± 0.10	13.70 ± 1.79**	0.99 ± 0.01
MPZP
Alcohol binge drinkers
0 mg/kg	1.04 ± 0.16	3.00 ± 0.15	0.65 ± 0.05
5 mg/kg	1.00 ± 0.43	3.18 ± 0.39	0.75 ± 0.08
10 mg/kg	1.06 ± 0.29	3.58 ± 0.42	0.71 ± 0.06
20 mg/kg	1.09 ± 0.26	3.80 ± 0.39	0.72 ± 0.07
Supersac controls
0 mg/kg	0.23 ± 0.08	22.18 ± 2.26	0.99 ± 0.00
5 mg/kg	0.19 ± 0.08	21.62 ± 2.07	0.99 ± 0.01
10 mg/kg	0.28 ± 0.06	22.29 ± 1.74	0.99 ± 0.00
20 mg/kg	0.23 ± 0.07	21.96 ± 2.25	0.98 ± 0.01

^**P<0.01 relative to vehicle condition;

N/A indicates denominator (total fluid intake) was zero for many of the individual rats.