Figure 4. IL-17A is upregulated in the tissue of IL-17R-deficient mice.
Basal expression of IL-17A was examined in organs of (A) IL-17R-deficient mice (open bars) compared to WT (filled bars) (n=3–4) and (B) Il17ra−/−Itgb2−/− mice (open bars) compared to Itgb2−/− mice (filled bars) (n=3–5). For the Il17ra−/−, Itgb2−/− and Il17ra−/−Itgb2−/− mice, the relative quantification (RQ) values were expressed as a fold-increase compared to IL-17A expression in WT mice (the calibrator control which is equal to 1). *p<0.05, **p<0.01 by unpaired students t test