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. Author manuscript; available in PMC: 2008 Nov 25.
Published in final edited form as: Lancet Neurol. 2008 Jul;7(7):615–625. doi: 10.1016/S1474-4422(08)70137-6

Figure 1. Lesion change in MS over time by use of a subtraction method involving image normalisation, inhomogeneity correction, and co-registration.

Figure 1

A new juxtacortical lesion (arrow) in a 44-year-old woman with relapsing-remitting MS who was scanned at baseline and after 3 years. The juxtacortical lesion is difficult to appreciate on the native spin-echo proton-density images, comparing the baseline (A) to follow-up scan (B), but is clearly visible on the subtraction image (C). In all images, the skull has been removed. Subtle artefacts are seen on the outer edge of the brain surface due to slight misregistration. Adapted with permission from the American Society of Neuroradiology.