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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Cell Biol Int. 2008 Jul 16;32(10):1238–1246. doi: 10.1016/j.cellbi.2008.07.007

Figure 4.

Figure 4

TGFβ pathway as affected by IGF2 administration based on Pathway-Express. There are 10 differentially expressed component boxes with an impact factor of 10.3. The upregulated genes include TGFβ (control: 0.57 ± 0.18, mean ± s.d.; IGF2: 2.3 ± 0.94), TGFβ RI (control: 0.85 ± 0.23; IGF2: 7.4 ± 12), Noggin (control: 0.47 ± 0.28; IGF2: 1.9 ± 0.53), THBS1 (control: 0.76 ± 0.25; IGF2: 2.7 ± 1.6), Smurf1 (control: 0.73 ± 0.14; IGF2: 2.0 ± 0.91), Smurf2 (control: 0.75 ± 0.25; IGF2: 1.8 ± 0.79) and Activin RI (control: 0.92 ± 0.12; IGF2: 7.3 ± 12) while the downregulated genes are Smad1 (control: 1.9 ± 0.62; IGF2: 0.53 ± 0.37), Id (control: 1.4 ± 0.41; IGF2: 0.65 ± 0.37) and Pitx2 (control: 1.6 ± 0.70; IGF2: 0.66 ± 0.27).