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. Author manuscript; available in PMC: 2009 Oct 15.
Published in final edited form as: FEBS Lett. 2008 Sep 18;582(23-24):3408–3414. doi: 10.1016/j.febslet.2008.09.001

Table 1.

IC50 values in MEFs

MEFs IC50 (nM)
vinorelbine cisplatin doxorubicin
RLIP76+/+ 2.2 ± 0.31 1520 ± 180 110 ± 20
RLIP76+/− 1.3 ± 0.15 830 ± 110 42 ± 8
RLIP76−/− 0.4 ± 0.03 360 ± 50 23 ± 3
RLIP76-liposomes treated RLIP76−/− 1.8 ± 0.22 1270 ± 185 86 ± 11

Drug sensitivity assays were performed using MTT (at 96 h) to determine IC50 values [23]. The values are presented as mean ± SD from three separate determinations with eight replicates each (n =24). Statistical analyses by ANOVA were significant at p< 0.01 for RLIP76+/+ vs. RLIP76+/−, RLIP76+/+ vs. RLIP76−/−, RLIP76+/− vs. RLIP76−/− and RLIP76−/− vs. RLIP76-proteoliposomes treated RLIP76−/−,