Figure 1.

Reciprocal effects of Gαi2 and Gαi3 on GVHD development. SCID BALB/c mice were each administrated intraperitoneally with 10⁷ T cells isolated from WT, Gαi2^−/−, and Gαi3^−/− mice on 129Sv/C57BL/6 background. Animals were monitored for weight (A) and survival (B) weekly. Note: significant acceleration of GVHD-associated morbidity in recipient of Gαi3^−/− T cells (**p<0.01) and reduction of the disease in recipient of Gαi2^−/− T cells (*p<0.05) as compared to mice receiving WT T cells. Results are from three (Gαi3^−/− T cells) or four (Gαi2^−/− T cells) independent experiments with 7∼12 mice per group in each experiment. The total number of mice was 31, 28 and 30 receiving WT, Gαi2^−/− and Gαi3^−/− T cells, respectively. Mean ± SD of weight changes relative to day 0 is shown in (A) (*p<0.05).