Figure 7.

Normal synapses are formed in Kal7^KO mice. A, Representative electron micrographs of hippocampal CA1 striatum radiatum synapses from adult Wt and Kal7^KO mice. Complete synapses (PSDs apposed to presynaptic endings with vesicles) were readily identified in Kal7^KO tissue. PSD length and thickness were measured. Cumulative frequency distributions of PSD length (C) and thickness (D) from Wt (solid line) and Kal7^KO (dashed line) mice are shown. Both PSD length (C) and thickness (D) were decreased in Kal7^KO mice. At least 800 randomly selected synapses from each of four Wt and four Kal7^KO mice were measured by observers blind to genotype. Differences are significant by Kolmogorov–Smirnov (p < 0.005).