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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: J Hand Surg Am. 2008 Nov;33(9):1548–1557. doi: 10.1016/j.jhsa.2008.05.030

Figure 1. Effect of growth factor to heparin ratio and PDGF-BB concentration on the rate of passive PDGF-BB release.

Figure 1

A) Effect of varying the growth factor to heparin ratio on release at constant PDGF-BB concentration (0.125 μg/μL) in the matrix. B) Effect of varying the growth factor concentration on release from fibrin matrices with no delivery system. C) Effect of varying the growth factor concentration on release from fibrin matrices with delivery system (PDGF:heparin ratio 1:1,000). Fibrin matrices containing HBDS and PDGF-BB were washed with 1 mL of TBS five times for the first 24 h and once every 24 h for the following 9 days. Percentage of cumulative PDGF-BB released was calculated by dividing the amount of PDGF-BB present in the wash cumulative by the total amount of PDGF-BB present cumulatively in both the wash and the matrix at the end of the study. ‘*’ denotes p<0.05 versus no delivery system over time. ‘#’ denotes p<0.001 versus the other two doses of PDGF-BB over time.