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. 2000 May 9;97(10):5574–5579. doi: 10.1073/pnas.97.10.5574

Figure 3.

Figure 3

Protease-resistant and detergent-insoluble PrP are widely distributed in the brains of Tg(PG14) mice. (A) Detergent insolubility of PrP from dissected brain regions was analyzed and quantitated as in Fig. 2 A and C. Each bar represents the mean ± SEM of three to five replicates from four Tg(PG14+/−) mice, ranging in age from 79 to 239 days. (B) Coronal cryostat sections from the brain of a Tg(WT+/+) mouse (182 days old) and a Tg(PG14+/+) mouse (192 days old) at the level of the caudate-putamen (rows 1 and 2), thalamus (row 3), and cerebellum (row 4) were subjected to histoblotting, either before (row 1) or after (rows 2–4) treatment with proteinase K.