Table 1.
Clinical illness in Tg(PG14) mice
| (C57BL/6J × CBA/J/Prn-p+/+)
|
(C57BL/6J × 129/Prn-p0/0)
|
|||
|---|---|---|---|---|
| Hemizygous | Homozygous | Hemizygous | Homozygous | |
| Age at onset | 235 ± 10 (61) | 68 ± 9 (7) | 243 ± 7 (76) | 64 ± 4 (28) |
| Age at death | 371 ± 21 (42) | 115 ± 12 (7) | 449 ± 17 (23) | 138 ± 10 (27) |
| Duration of illness | 154 ± 14 (35) | 49 ± 11 (5) | 233 ± 18 (20) | 92 ± 9 (19) |
Entries show the mean number of days ± SEM. The number of animals in each group is given in parentheses. Hemizygous and homozygous refer to the status of the PG14 transgene array. Data are for mice belonging to the Tg(PG14-A2) and Tg(PG14-A3) lines.