Fig. 3.

Morantel increases the frequency of single-channel openings. A, representative single-channel current traces are shown from an experiment using 10 μM ACh alone (top) and with 10 μM morantel added (bottom) to the same outside-out patch held at −60 mV. Traces are not continuous; filtering was at 5 kHz. Downward deflections are the brief openings. The trace marked with * in each set is shown at the higher time resolution as the bottom trace in each set. B, the frequency of channel openings, calculated as averages in 10-s bins to approximate an “instantaneous” measure, is plotted for each entire 300-s recording for the experiment shown in A. The dashed lines indicate the overall average frequencies of 1.5 s⁻¹ for ACh alone and 5.1 s⁻¹ in the presence of morantel.