Skip to main content
. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Mol Cancer Ther. 2008 Oct;7(10):3363–3372. doi: 10.1158/1535-7163.MCT-08-0439

Figure 6. DIM-C-pPhBr inhibits tumor growth in an orthotopic model for pancreatic cancer.

Figure 6

Tumor weights (A) and volumes (B). Male athymic nude mice bearing L3.6 pl cell xenografts were treated with DIM-C-pPhBr (25 mg/kg/d) or control (corn oil) for 4 weeks, sacrificed for necropsy and tumor weight and volumes were determined as described in the Materials and Methods. Asterisk indicates significant (p<0.05) decrease in tumor weight and volume in animals treated with DIM-C-pPhBr. (C) TUNEL assay. Fixed tumor sections from DIM-C-pPhBr treated animals exhibited increased apoptosis in the TUNEL assay as described in the Materials and Methods. (D) Model for C-DIM induced responses. The model depicts activation of ER stress-dependent and independent activation of JNK in pancreatic and colon cancer cells respectively and also stress-dependent activation of DR5 in pancreatic cancer cells.