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Circular ROIs (diameter, 15 mm) were manually placed over the most metabolically active part of tumor, as seen in last frame of dynamic 18F-FDG images (A). ROIs were defined in 3 adjacent image slices (not shown). This volume of interest was subsequently applied to 2 15O-water image series (B and C) under assumption that patient did not move between 15O-water and 18F-FDG studies.
