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. Author manuscript; available in PMC: 2009 May 1.
Published in final edited form as: Trends Cardiovasc Med. 2008 May;18(4):141–149. doi: 10.1016/j.tcm.2008.04.001

Figure 1.

Figure 1

Mapping of myosin motor domain and rod domain mutations. Black columns correspond to the total number of observed mutations (similar plus dissimilar), dotted and striped columns correspond to the number of similar and dissimilar observed mutations, respectively. White columns correspond to the theoretical number of expected mutations. (A) Distribution of total mutations present in the myosin motor domain and rod. * indicates that the observed number of mutations is significantly different than expected (p < 0.01). (B) This analysis was carried out using a scanning smoothing window of 56 amino acids. The x-axis corresponds to the amino acid position; the y-axis corresponds to the number of mutations. The boundary between the motor domain and rod is shown at the top of the graph. (C) Number of similar and dissimilar mutations present in the whole myosin molecule. * indicates that the observed number of mutations is significantly different than expected (p < 0.05). (D) Number of similar and dissimilar mutations present in the motor domain. * indicates that the observed number of mutations is significantly different than expected (p < 0.01) (E) Number of similar and dissimilar mutations present in the rod. * indicates that the observed number of mutations is significantly different than expected (p < 0.05).