Figure 10.
Effects of wt and G299R hBest1 on native CaV currents in RPE-J cells. A, Representative current traces evoked by −10 mV test pulse from native, hBest1 transfected, and G299R hBest1 transfected RPE-J cells. B, I–V relationships for native CaV channel (open circles), with wt-hBest1 (filled circles), or G299R-hBest1 (triangle). C, Averaged Ba2+ current densities at 0 mV for native CaV either alone or with additional wt-hBest1 and G299R mutant. **p < 0.001 for Ca channel plus hBest1 compared with Ca channel alone by two-way ANOVA.