Table 1.

Differences between Type I and Type II cells

Phenotype	Type I	Type II
CD95 expression1	High	High
Potential for CD95 apoptosis sensitivity2	High	High
CD95 apoptosis kinetics2	Fast	Fast
Constitutive localization of CD95 in lipid rafts3	Yes	No
Recruitment of CD95 to lipid rafts upon stimulation3	No	Yes
DISC formation2	High	Low
hiDISC formation on endosomes5	Yes	No
Cytochrome c release from mitochondria2	Yes	Yes
Protection from apoptosis by Bcl-2/Bcl-xL2	No	Yes
Apoptosis is actin-dependent6	Yes	No
Apoptosis sensitivity to soluble CD95 ligand7	No	Yes
Sensitivity to actin disrupting drugs7	Low	Low
Sensitivity to Taxanes7	Low	High
Sensitivity to C2-ceramide8	No	High
Inhibition of apoptosis by activating PKC8	Low	Yes
Expression of let-79		High

¹[8, 10]

²[8]

³[17–19]

⁴[15, 16]

⁵[25]

⁶[115]

⁷[10]

⁸[14]

⁹[49].