Table 3.

Immunoreactive IL-1β levels

Treatment	Striatum	Cortex	Hypothalamus
After 3 h
Sham	ND	ND	ND
Vehicle	32  ± 4	28  ± 1	20  ± 3
S-AMPA	28  ± 6	86  ± 23	26  ± 7
hrIL-1β	29  ± 3	56  ± 20	41  ± 4
S-AMPA + hrIL-1β	47  ± 9	128  ± 27*	56  ± 9**,†
After 8 h
Sham	ND	ND	ND
Vehicle	157  ± 46‡	65  ± 20	18  ± 3
S-AMPA	48  ± 7	72  ± 10	35  ± 7
hrIL-1β	304  ± 70††,‡	147  ± 41	128  ± 30**,†,‡
S-AMPA + hrIL-1β	241  ± 34†,‡‡	870  ± 186***,†††,‡,§§§	186  ± 27***,†††,‡

Expression of immunoreactive rat IL-1β (pg IL-1β/mg protein) in different regions of the rat brain 3 h and 8 h after intrastriatal injection (n = 4–6) of vehicle, S-AMPA (7.5 nmol), hrIL-1β (10 ng) or S-AMPA (7.5 nmol) + hrIL-1β (10 ng). ∗, P < 0.05; ∗∗, P < 0.01; ∗∗∗, P < 0.001 vs. vehicle. †, P < 0.05, ††, P < 0.01, †††, P < 0.001 vs. S-AMPA. ‡, P < 0.05; ‡‡, P < 0.01 vs. 3 h; §§§, P < 0.001 vs. hrIL-1β. ND, not detectable.