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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Hepatology. 2008 Nov;48(5):1558–1569. doi: 10.1002/hep.22499

Fig.1. The locations of PFIC II mutations and ΔGly in Bsep.

Fig.1

The positions of G238V, D482G, G982R, R1153C and R1286Q are indicated by star signs in a predicted topology model of rat Bsep. The Walker A and B regions are shown in boxes and a number of potential glycosylation sites are indicated by the branch structures in the first extracellular loop of Bsep. ΔGly represents a mutation that lacks the potential glycosylation sites. The orientation of the plasma membrane is indicated.