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. Author manuscript; available in PMC: 2008 Nov 25.
Published in final edited form as: Dev Dyn. 2007 May;236(5):1161–1174. doi: 10.1002/dvdy.21115

Figure 5. Increasing levels of FGF2 or Shh increases mitosis.

Figure 5

PH3 labeling of mitotic cells from E4 retinectomized eyes exposed to FGF2 or Heparin beads in vivo for 24 hours revealed that FGF2 significantly increased the number mitotic cells in the NPE of the CB/CMZ (left). Eyes were also injected with Rcas-Shh or Rcas-GFP at E3 and retinas removed at E4. Eyes were collected, sectioned and assayed for PH3 positive cells 24 hours after retinectomy. Ectopic Shh significantly increased the number of mitotic cells in the NPE of the CB/CMZ (right) *=p<0.05, n=6 sections from 3 eyes. Heparin beads represent the negative control for FGF treatments and Rcas-GFP the control for Shh treatments. Error bars are S.E.M.