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. Author manuscript; available in PMC: 2008 Nov 25.
Published in final edited form as: Dev Dyn. 2007 May;236(5):1161–1174. doi: 10.1002/dvdy.21115

Figure 7. FGF and Hh signaling promote cell survival in the NPE of the CB/CMZ.

Figure 7

A. Retinectomies were performed at E4 and chick eyes were exposed to 200uM KAAD, 50uM PD173074 or DMSO control beads for 4 hours. Exposure to KAAD (* = p<0.01) and PD173074 (* = p<0.001) significantly increased the number of TUNEL positive cells in the NPE of the CB/CMZ, whereas exposure to PD173074 did not. n=6 sections from 3 eyes. Error bars are S.E.M.

B. Retinectomies were performed at E4 and chick eyes were exposed to 200uM KAAD, 50uM PD173074 or DMSO control beads for 24 hours. Exposure to KAAD and PD173074 did not increase the number of TUNEL positive cells in the NPE of the CB/CMZ, n=6 sections from 3 eyes. Error bars are S.E.M.

C. Retinectomy was performed on E4 chick eyes. Eyes were then exposed to FGF2 or DMSO control beads (left); Rcas-Shh or Rcas-GFP control (middle); DMSO control beads or DMSO control beads plus a piece of retina (right). Treatment with FGF (*=p<0.001), Rcas-Shh (*=p<0.05) or DMSO control plus retina (*=p<0.001) were all able to significantly reduce the number of TUNEL positive cells compared to their respective controls.